Alzheimer's Disease And Glutathione

What is Alzheimer's Disease?


Alzheimer's disease is a progressive, degenerative neurological condition caused by nerve cell death resulting in atrophy of the brain.

Alzheimer's is the most common form of dementia,which is predicted to become the number one health issue in Australia this century. The incidence of Alzheimer’s disease is increasing. It is thought that three percent of people aged 65- 74 have the disease and those over 85 have a higher risk closer to fifty percent.

Symptoms of Alzheimer's Disease

Alzheimer's disease is defined as "an irreversible, progressive brain disease that slowly destroys memory and thinking skills, eventually even the ability to carry out the simplest tasks”
Early symptoms of the disease, often mistakenly attributed to aging or stress, include irritability, aggression and mood swings. There can also be subtle problems with planning, attentiveness, flexibility, apathy and memory impairment. These early mild symptoms may present many years before the clinical signs of disease are evident. As the disease advances however, significant confusion, language difficulties and memory loss occurs.

What causes Alzheimer's Disease?

Scientists do not yet fully understand the causes of Alzheimer’s disease (except for the 1 – 5% of cases which have a genetic basis).

There is growing evidence that lifetime exposures to toxins, chemicals, poor diet and oxidative stress are all factors, triggering inflammatory processes and a build up of beta amyloid plaque in the brain cells’ mitochondria.

Glutathione depletion is known to be a key factor in Alzheimer’s Disease.
Electromagnetic Radiation


Scientific studies have shown that exposure to electromagnetic radiation significantly increases the risk of Alzheimer’s, or can make it rapidly worse. Wi-fi, cordless telephones and mobile phones all create microwave radiation which has been shown in scientific studies to cause genetic mutations in brain cells. These mutations may lead to dementia or cancer.

Heavy Metal Toxicity

Another part of the puzzle is exposure to toxic heavy metals. Aluminium was originally thought to be the main offender although today we realise that mercury poisoning seems a far more likely culprit. We are exposed to very high levels of mercury from dental amalgam and various dietary sources, such as fish. Chelation can remove these toxic metals from the tissues. Some doctors have recognized the value of chelation for Alzheimer's and other degenerative disorders caused by metal poisoning and have found it to be very effective at restoring the function of older blood vessels and brain cells. Glutathione is able to chelate these toxic metals.
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The Glutathione Connection

“Loss of intracellular neuronal glutathione (GSH) is an important feature of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects.” (ref Du et al, Free Radical Biology and Medicine 2008)
Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases, including Alzheimer's and Parkinson's disease. Scientists have demonstrated that supplementing with glutathione precursors can product beneficial effects in slowing the progression of these diseases.

Dr David Perlmutter observed what he called the "glutathione miracle" when he gave patients with severe Parkinson's disease intravenous glutathione. Within one hour they were able to stand, walk and move their arms around again normally. He has also used glutathione extensively in cases with Alzheimer's and other dementias, multiple sclerosis, strokes and chronic fatigue with success.

Watch this testimonial

This lady tells about how difficult it is with a husband who has Alzheimer's Disease because of their sudden mood swings and tantrums. Her husband has been suffering for 4 years when a friend recommended Max products - and yes, despite all the other food supplements recommended to them before that did not work - she gave Max products a try. She purchased one box of Maxgxl with 4 bottles. After a week or so, on the 3rd bottle of Maxgxl, she noticed her husband calmed down, was able to sleep well and no longer restless even at night. As of this testimony, her husband has been ill for 8 years, but thanks to Max products Alzheimer's Disease has been manageable

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The amazing health benefits behind this Master Antioxidant Glutathione

What is Glutathione?

Glutathione is a molecule that is continuously made by the body and exists in every cell of the body. It is also found in vegetables, fruits and meats. Glutathione is a protein that is made up of three amino acids: glycine, glutamine and cysteine. It protects cells, tissues and organs against oxidative stress caused by free radicals.

Research over the last decade has shown that it is the most potent antioxidant and detoxifier surpassing vitamin A, C and E. Glutathione is essential for the immune system to function properly, and it helps the nutrients you eat do their job. Without it, even with a well-balanced diet, your body would not be able to make use of all the nutrition you were consuming.

Glutathione is second to no other nutrient or supplement because without it, there could not be life. An embryo that develops with a defect that prevents it from producing glutathione cannot live. Adults with a genetic defect that leaves them with the inability to control glutathione continuously have to deal with numerous health problems - some of them fatal.

The Role of Glutathione in the Body

Primarily, glutathione ensures that other nutrients and antioxidants do their job properly, and it ensures you get the energy you need to function. The result is you feel stronger, look younger and can live longer. The following are key benefits that explain why this is the case.

Glutathione helps to:

• Reduce intracellular inflammation
• Support the immune system and fight against minor as well as serious diseases
• Reduce muscle recovery time and build strong muscles
• Ensure the production of energy of each cell by protecting the mitochondria
• Fight against free radicals and prevent damage to cells
• Slow down the ageing process

A function of glutathione that needs special mentioning is its role in energy production. Each cell has a mitochondria, which is where respiration takes place and energy is produced. The mitochondria is extremely vulnerable to free radical damage. When the mitochondria is damaged, the cell quickly deteriorates. The presence of glutathione is what protects the mitochondria from free radical damage, allowing the cell to continue its normal function. Having all your cells equipped with a healthy mitochondria that can produce continuous energy enables you to be a stronger person.

Glutathione as a Leading Antioxidant and Detoxifier

Although glutathione is present throughout the body, it is specifically important for the functioning of the liver. The liver is one of the vital organs in the body, and it has one of the hardest jobs. It is responsible for getting rid of toxins, making biochemicals necessary for digestion and protein synthesis. It also stores glycogen, has a role in metabolism and the decomposition of red blood cells and assists in hormone production.

Medications such as acetaminophen and drinking too much of alcohol are some examples of what can greatly increase the toxic load of the liver. The toxins build up fast causing a huge amount of pressure on the liver, and if it doesn't have adequate amounts of glutathione, the liver can't do its job.

In fact, think of the liver as the cleaner and maintainer of your body, and every cleaner needs the proper tools to do the job properly. Glutathione is the tool the liver needs. It is the essential ingredient that will allow the liver to get rid of toxins, produce the biochemicals, hormones and energy required for the body to function.

Vitamins A, C and E have been known to be powerful antioxidants for years; however, nutritionist now believe that glutathione is the leader of all antioxidants in the fight against free radicals. An antioxidant is a molecule that prevents the oxidation of other molecules. Oxidation can produce free radicals, which in turn can begin chain reactions in a cell. When this happens, it damages the cell and can kill it. A damaged cell leads to cancer and other diseases. Glutathione already exists in each cell and actually helps to get the most out of all the other antioxidants. This is what makes it a super antioxidant, and it is why nutritionist believe it is a very powerful tool against ageing, cancer and other diseases.

Glutathione has an important role as a detoxifier. Antioxidants also rid the body of toxins, which reduces inflammation throughout the body. Research has shown that inflammation is the leading cause of many diseases such as arthritis and heart disease. Persistent inflammation can also make a person age prematurely. Because the skin is not able to repair itself, it leads to puffiness and reduces the elasticity of the skin. This causes wrinkles to appear sooner than they normally would have to.

Natural Production and Decline of Glutathione

Nature does not usually get things wrong. If it is making glutathione in each cell in the body, that itself shows how important it is for the body to function. Even though the body makes this essential nutrient, daily exposure to medications, stress, pollution, infections, radiation and a poor diet all lead to the depletion of glutathione in the body. As you age, your body's ability to produce glutathione reduces.

A deficiency in glutathione has been associated with:

• Cancer
• Alzheimer's and other age related diseases
• Diseases related to inflammation, such as asthma and arthritis
• Slowing down of muscle recovery time
• General muscle weakness and low energy levels
• A failing immune system

Starting at about 20 years of age, the body begins to slow down the production of glutathione. By the time you are 50 years old, your body only has 60 to 70 percent of the glutathione it had in your teens. This shows a clear connection as to why diseases begin to set in as you grow older.

It is not possible to live without being exposed to all the things that reduce glutathione in the body. This is why it is important to ensure you are getting sufficient amounts through your diet and a supplement.

How to Boost Glutathione Levels in Your Body

Unlike most chemicals, nutrients and enzymes, glutathione cannot just be taken as a pill to increase levels in the body because it does not survive the digestive process, and so the body cannot absorb it. Researchers were frustrated by this fact for years. They saw that giving glutathione intravenously had a more positive outcome; however, it was only marginally more effective in the body's ability to absorb it. It was also an expensive and inconvenient way of having to take it.

Researchers finally discovered that giving the body the nutrients it needs to produce its own glutathione was the only way to increase and maintain high levels in the body.

Here is a look at some of the most effective ways you can help your body increase production of glutathione. These foods are high in amino acids, which is what the body uses to produce glutathione.

Vegetables and Fruits: Brussels sprouts, cabbage, kale, cauliflower, broccoli, avocados, tomatoes and spinach, onions, garlic, kiwi, bananas, melons, strawberries and grape fruit. It is important to remember you only get the full benefits of these vegetables and fruits when they are eaten raw.

Dairy and Meat: To get the most benefit from dairy and meat products, they need to be consumed unprocessed and raw. This is because once they are cooked, their nutritional value for increasing glutathione is negligible.

Herbs: Milk thistle is a good source of the antioxidant compound silymarin, which helps to maintain high levels of glutathione in the liver.

Whey Protein: Whey is packed with amino acid building blocks essential for glutathione synthesis. However, you have to make sure you are buying whey made from non-pasteurized milk. It also needs to be made from dairy free of pesticides, hormones and antibiotics.

Exercise: Physical activity is just as important as your diet. Exercise boosts your glutathione levels.

Supplements: Researchers collaborated with Max International and patented a formula known as Max Cellgevity that allows the body to naturally increase glutathione. This formula has proven to be very effective, and in some cases, an increase of 300 percent was recorded. The immense positive evidence proves that it is the only product available today that is effective in increasing glutathione.

Unfortunately, research has shown that eating a healthy diet is not enough for your body to produce more glutathione. Clinical test showed that there was only a slight increase in those who tried to increase their levels by diet alone. A supplement such as Max Cellgevity will do wonders and give you results you can feel much quicker.

Although a supplement is the best way to increase and maintain glutathione levels, it does not eliminate the need for a healthy diet and exercise. Remember, the main role of glutathione is to ensure your body utilizes all the nutrients you consume, so they can do the best job possible.

Cellgevity Riboceine Glutathione Enhancer (NENUSA000602)

Cellgevity Riboceine Glutathione Enhancer (NENUSA000602)

Max Your life with enhanced RiboCeine Technology
The advanced GLUTATHIONE support all cells deserve
* Advanced RiboCeine formula featuring 12 supplemental ingredients
1. Alpha Lipoic Acid
2. Broccoli seed extract
3. Turmeric root extract
4. Resveratrol
5. Grapeseed extract
6. Quercitin
7. Milk Thistle
8. Vitamin C
9. Selenomethionine
10. Cordyceps
11. Black pepper
12. Aloe extract
**Provides cellular protection from cell damaging free radicals
**Support cellular function

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Lifestyle Changes To Help Prevent Gallstone Formation

#HealthTrivia #Gallstone

PREVENTION is better than CURE!

LIFESTYLE CHANGES TO HELP PREVENT GALLSTONE FORMATION DIET:  

• Eat whole grains, unrefined carbohydrates (brown bread, rice and pasta etc) and plenty of dietary fibre.
• Increase intake of vegetable proteins (especially soy products), decreasing intake of animal proteins.
• Consume plenty of fresh, organic fruit and vegetables, especially those containing pectin (especially green apples) and cellulose (especially celery and crisp fruits and vegetables).
• Eliminate intake of saturated fats, and ALL products containing white sugar and white flour.
• Eat no fried foods, especially those that are deep-fried.
• Avoid ice-cold foods and drinks - room temperature or slightly warm is best.
• Avoid coffee.
• Drink at least 6-8 glasses of water per day to keep the water content of your bile topped up, plus chamomile tea if possible
• NEVER skip meals and ALWAYS eat breakfast.
• Every meal or snack should contain 10g of fat to enable the gallbladder to contract.
• Drink a little unrefined, cold-pressed extra virgin olive oil each day (see Daily Flush Drink above). Olive oil will help the gallbladder to contract vigorously and thus cleanse itself.
• Do not eat excessively large meals, which put an unnecessary burden on the digestive system.
• Vegetarians have a much lower incidence of gallstones, so adopting a vegetarian diet will certainly help.

Helpful supplements include

Vitamin E (200iu per day, to help prevent and dissolve gallstones), Vitamin A (helps to keep the mucosal walls healthy, preventing excess dead cells from entering the gallbladder and bile), Vitamin B Complex (helps to empty the gallbladder more efficiently), Vitamin C (helps to convert cholesterol into bile acids and render it harmless), omega-3 oils (flaxseed etc), soya lecithin (a fat emulsifier; helps keep cholesterol in solution), the amino acid tausine, psyllium husks (an excellent source of gel-forming, non-irritating dietary fibre, which alters the synthesis and absorption of secondary bile acids that form in the intestinal tract), milk thistle and dandelion tinctures (which increase the production and flow of bile), peppermint capsules/tablets (enteric coated; keeps cholesterol crystals from forming in bile), chamomile tea and good quality antioxidants (antioxidants deficiencies can inducegallstone formation). Turmeric spice is also helpful.

Need a food supplement to dissolve gallstones for good? Message me

Christine Bulchmann

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Glutathione - Why Is It So Important?

This article will demonstrate to you why Glutathione is so important to your health and well-being.

Glutathione (pronounced 'gloota-thigh-own') is the body's essential health ABC's – 
Antioxidant, Blood Booster and Cell Detoxifer.

It is a tripeptide composed of glutamic, cysteine and glycine. Glutathione is found in all cells in the body, including the bile, the epithelial lining fluid of the lungs, and - at much smaller concentrations - in the blood.

Glutathione is the smallest intracellular non-protein thiol (molecule containing an S_H or sulfhydryl group) molecule in the cells. This characteristic emphasizes its potent antioxidant action and supports a
multifaceted thiol exchange system, which regulates cell activity.

This small protein, produced naturally in the body, maintains these three crucial protective functions.
In fact, your life depends on glutathione. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to metabolic acids, and your liver would shrivel up from the eventual accumulation of acidic toxins.

Glutathione is not yet a household word. Even some medical and holistic doctors who have heard the term may still have only a vague idea of what it is. However, everyone will soon be talking about this critical
non-nutritive substance.

There was a time when only scientists had heard of cholesterol and vitamins, but today, everyone knows about them. Now the magnificence of glutathione is becoming known.

In the last five years, over 25,000 medical articles about this substance have been published, and the scientific understanding of glutathione is gradually becoming common knowledge.

Each and every cell in the body is responsible for its own supply of glutathione and must have the necessary raw materials in order to produce it. Glutathione is always in great demand and is rapidly consumed when we
experience any sort of emotional or physical stress, fatigue and even moderate exercise.

Some well-known causes of glutathione depletion are as follows:

1) Acidic lifestyle and diet
2) Air and Water pollution
3) Prescription and recreational drugs
4) Ultraviolet and Radiation from cells phones, computers, electrical cars, power lines, hair dryers, etc.
5) Emotional and physical stress
6) Injury, trauma or burns
7) Heavy metals
8) Cigarette smoke
9) Household chemicals
10) Acetaminophen poisoning
11) Exhaust from motor vehicles
12) Septic shock

All of these above factors lead to a build up of acidic toxins that cause
the loss of glutathione as a non-nutritive buffer leading to cellular aging,
disease and finally death.


Why is Glutathione Essential to Health?

Glutathione's three major roles in the body are summarized by the letters A-B-C.

- Anti-oxidant
- Blood Booster
- Cell Detoxifier

These are the three critical processes driven by glutathione.

The Master Antioxidant

Over the past thirty years, researchers have explored the role of antioxidants in good health as well as the treatment and prevention of diseases involving oxidation or fermentation by metabolic acids.

Well known and widely used antioxidants such as vitamin A, vitamin E and selenium neutralize acid. They occur naturally in nature, but not in the body. They must be introduced as part of a balanced diet.

Given the critical role of antioxidants in good health, it is not surprising that the body itself manufactures its
own natural antioxidants. The most important of these is glutathione. Because all other antioxidants
depend upon the presence of glutathione to function properly, scientists call it 'the master antioxidant.'

Glutathione binds to toxins, forming a water-soluble complex - which is ultimately excreted in the urine or bile as waste.

Food for the Blood

Elevated glutathione levels enable the body to produce more white blood cells. White blood cells are the body's garbage collectors and are the most important cells for maintaining sterility of the body fluids.

Glutathione plays a central role in the proper function of the white blood cells. Dr. Bustavo Bounous, a leading glutathione expert, says, 'The limiting factor in the proper activity of our lymphocytes (the white blood
cells) is the availability of glutathione.' In other words, healthy growth and activity of the white blood cells depends upon glutathione's availability. Put simply, glutathione is 'food' for the white blood cells.

Cellular Detoxifier

Whether we know it or not, we are continually inhaling and ingesting natural and synthetic acidic toxins. They are unavoidable in these modern times both in our polluted cities and our poorly engineered food supplies. When the body has the health and the nourishment it needs, it works tirelessly to eliminate acidic toxins and to protect itself. But, increasing levels of environmental pollution are depleting the body's store of glutathione more and more rapidly. Our main organ of detoxification of acidic waste products is the lymphatic
system and the liver. This is the body's most concentrated source of glutathione.

Studies show that low glutathione levels lead to poor lymphatic and liver function, causing more and more acidic toxins to circulate through the body and resulting in damage to individual cells and organs.

Medical doctors today routinely use glutathione- promoting drugs to detoxify victims of certain types of drug overdose.

Glutathione in Natural Medicine

Practitioners of complementary and alternative medicine (CAM) have long advocated the use of milk thistle for liver problems. It turns out that this herb works by modestly elevating glutathione levels. The mineral
selenium also produces subtle elevations in glutathione by becoming integrated into the glutathione peroxidase.

Glutathione in Traditional Medicine

Emergency medical doctors, toxicologists and lung and liver specialists are well acquainted with glutathione's therapeutic uses. American physicians seeking ways to raise a patient's glutathione levels can open the standard Physician's Desk Reference (PDR) and find two options - the pharmaceutical drugs sold under the names Parlodex and Mucomyst, and the natural dietary supplement found in natural foods stores derived from whey protein isolate.

Drugs That Raise Glutathione Levels

Pharmaceutical drugs like Procysteine, OTC, OTX, Glutathione monoesters and Glutathione diesters have been used to raise glutathione levels. However, they all produce side effects and are unsuitable for long term use.
This pharmaceutical non-nutritive chemical is used to break up mucus in lung diseases such as cystic fibrosis, chronic bronchitis and asthma. It remains the standard treatment for acetaminophen overdose.

Glutathione in Health and Disease

It is believed that glutathione has an important role to play in the prevention and treatment of disease.
It may in the future be considered as important to health as an alkaline diet, exercise and alkaline lifestyle. Clinical tests show that raised glutathione levels may address some of the eight major health issues of our time:

1) Cardiovascular

- Prevents heart disease - Shimizu H, Kiyohara Y, Kitazono T, Kubo M, Ibayashi S, Fufishima M, Lida M.
Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study. Stroke. 2004 Sep; 35(9):2072-7.
- Prevents stroke - Paterson PG, Juurlink BH. Nutritional Regulation of Glutathione in Stroke. Neurtox Res. 1999 Dec; 1(2): 99-112.
- Prevents atherosclerosis - Coppola L, Grassia A, Giunta R. Glutathione Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic Subject. Drugs Exp. Clin Res 1992 18:493-98

- Reverses artherosclerosis
- Prevents reperfusion injury

2) Cancer

Cancer causing polychlorinated biphenyls (PCBs) have been found to alter levels of glutathione compounds in experiments, which may alter the body's resistance to certain types of cancer.

Glutathione deficiencies have been linked to many forms of cancer.

- Prevents cancerous tissue
- Suppresses tumor growth
- Eliminates carcinogen - acids
- Retards oxidative stress
- Prevents wasting disease
- Eases side effects of chemotherapy and radiotherapy

3) Pulmonary

Glutathione is the most efficient free radical (acid) scavenger in the airways, and dozens of studies have confirmed that free radical (acid) damage is a primary player in Chronic Obstructive Pulmonary Disease. Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54.

- Breaks up mucus - Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54

- Cystic fibrosis - Glutathione neutralized harmful oxidants introduced into the lungs or those released by cells. Exotoxins from bacteria can overload the endobronchial terrain and feed the fires of acidic inflammation. This
staggering burden increases the oxidative sensitivity of the CF lung, resulting in further injury of lung parenchyma. Data supports evidence of a decrease in the antioxidant tri-peptide glutathione (Roum JH, Buhl R, McElvaney NG, et al. Systemic Deficiency of Glutathione in Systic Fibrosis. J Appl Physiol 1993; 75:19-24).

- Asthma
- Chronic bronchitis

- Emphysema - Lamson, David, MD, Grignall, Matthew, ND. The use of Nebulized Glutathione in the Treatment of Emphysema: A Case Report. Altern Med Review. 5(5);429-431, 2000 Oct.


- Pulmonary fibrosis - Ishii T, Fujishiro M, Nakajima J, Teramoto S, Ouchi Y, Matsuse T. Depletion of Glutathion S-Transferase P1 Induces Apoptosis in Huamn Lung Fibroblasts. Exp Lung Res. 29(7);523-36, 2003 Oct-Nov.

4) Aging

Glutathione is critically important to our brain as it is one of the most important brain antioxidants.
Glutathione helps preserve brain tissue by preventing damage from free radicals (acids).

In addition to quenching dangerous acids, glutathione also acts to recycle vitamin E which also has the ability to reduce acidity in the brain. (Perlmutter D., BrainRecovery.com July 2004, 5th ed:13)

- Autism - Medical literature documents that an out-fection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant's or toddler's nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)

- Parkinson's Disease - Glutathione helps to preserve brain tissue by preventing damage from free radicals (acids) and destructive chemicals formed by the normal processes of metabolism, toxic elements in the
environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection many be lacking in
the brains of Parkinson's clients due to glutathione deficiency, it can be seen as very beneficial.
(Di Monte DA, Cahn P, Sandy MS. Glutathione in Parkinson's Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111-115, 1992.)

- Alzheimer's Disease - Woltjer, R.L., Hgheim W., Maezawa I., Vaisar T, Montine K.S., Montine T.J., Role of Glutathione in Intracellular Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and
Associated Cytotoxicity. J Neurochem. 2005 May; 93 (4): 1047-56.

- Huntington's Disease - Choo Y.S., Mao Z, Johnson GV, Lesort M. Increased Glutathione Levels In Cortical Striatal Mitochondria of the R6/2 Huntington's Disease Mouse Model. Neuroscience Letter. 2005 Sep 23; 386(1): 63-8.

- Multiple Sclerosis - Calabrese V, Scapaginini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. Disruption of Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of
Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine. 2003 Sep; 28(9):
1321-8. Mann CL, Davies MB, Aldersea J, Fryer AA, Jones PK, Ko Ko C, Young C, Strange RC, Hawkins CP. Glutathione S-Transferase Polymorphisms in MS: Their Relationship to Disability. Neurology. 2000 Feb 8;54(3):542-7.

- ALS - Tohgi H, Abe T, Yamazaki K, Murata T, Ishizake E, Isobe C. Increase in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis. Neurosci Lett. 1999 Feb 5; 260(3):204-6.

- Cataract formation
- Macular degeneration
- Cancers of aging
- Prostate problems

- Osteoarthritis - Hammarqvist F, Luo JL, Cotgreave IA, Andersson K, Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill Patients. Crit Care Med. 25(1):78-84 1997 Jan.

5) Digestive

- Inflammatory bowel disease
- Hepatitis
- Malnutrition
- Pancratititis
- Peptic ulcer

6) Toxicology

- Detoxifies certain drug overdoses - Acetaminophen has been shown to reduce glutathione production, thus paving the way for enhanced brain destruction by metabolic acids. (Perlmutter D. July 2004, 5th ed:108)

- Detoxifies substances in cigarette smoke and auto exhaust - Rahman I, MacNee W. Lung Glutathione and Oxidative Stress: Implications In Cigarette Smoke-Induced Airway Disease. Am J Physiol. 277(6 Pt 1);1067-88, 1999 Dec.

- Detoxifies pollutants including heavy metals and pesticides – Elevated glutathione levels have been shown to protect tissue form lipid peroxidation created by exposure to certain metals. Consider infusions of glutathione to relieve the body burden of both neurotoxins and metal toxicity, including mercury. (Foster, JS. Kane PC, Speight N. The Detox Book. 2002;90)

- Prevents hearing loss from noise pollution
- Detoxifies many well-known carcinogens

7) Immunology

- Anti-viral for AIDS, hepatitis, herpes, etc. - Low glutathione levels in HIV clients may contribute to their immune deficiency since glutathione plays an important role in the function of lymphocytes. Some lymphocytes require adequate levels of glutathione in order to function normally, and HIV induces oxidative stress that depletes the cells of glutathione. Townsend DM, Tew KD, Tapero H. The Importance of Glutathione in Human Disease. Biomed Pharmacother. 2003 May-June;57(3-4):145-55. Droge W, Holm E. Role of Cysteine and Glutathione in HIV Infection and other Diseases Associated with Muscle Wasting and
Immunological Dysfunction. FASEB J, 11(13):1077-89 1997 Nov.

- Lyme Disease - Lyme disease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a
soluble compound with them, which can then be excreted through the urine or gut. (Can Glutathione Help Lyme Disease Suffers? Excerpt from: The Glutathione Report: Opitmal Health with the Master Antioxidant, Issue 4, Volume 1, May 2004).

- Natural antibiotic

- Chronic fatigue syndrome - An article in the journal of Medical Hypothesis proposed that glutathione, an anitoxidant essential for lymphocyte function, may be depleted in Chronic Fatigue Syndrome patients. Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and myalgia associated with Chronic Fatigue Syndrome (Bounous et al. 1999).

8) Metabolic

- Athletic enhancement
- Decreases recovery time from physical stress
- Supports hemoglobin in kidney failure

- Diabetes - The blood and tissues of diabetics are marked by critically low glutathione levels. Glutathione depletion may have adverse consequences in diabetic clients independent of glycemic control, and it may
weaken the defense against oxidative stress. De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C, Falsano F. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism. 1998 Aug;47(8):433-8.

Glutathione provides the body with tools to fight off these threats naturally. Healthy people also benefit from elevated glutathione levels through an enhanced ability to fight off acidic toxins, disease, pre-cancerous cells and the aging process itself. Diminished glutathione levels are a symptom of aging and are particularly evident in such aliments as Parkinson's disease and Alzheimer's disease.



Glutathione is also important to physically active people. Many world-class athletes are discovering that well-maintained glutathione levels gives them the edge over their competitors, bringing greater strength and endurance ,decreased recovery time from injury, less muscle pain and fatigue, and muscle-promoting activity.


Putting It All Together

1) Medical science is still ascertaining all the critical roles played by glutathione in disease resistance and general good health. Clinical evidence links low glutathione levels to the most common illnesses of our
time as well as newly emerging diseases.

2) As an essential aid to health, glutathione works as the master antioxidant in our body, optimizes the white blood cells and detoxifies a long list of pollutants and carcinogens or acids. The best way to raise glutathione levels is by eating foods that are high in glutathione such as avocados.

3) Pharmaceutical medicine has created drugs that do this very effectively. They have their uses in critical situations. But they also have side effects and repeated use is clearly inadvisable.
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References:

Aging

It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging including cataracts, Alzheimer's, Parkinson's atherosclerosis and others.

Journal of Clinical Epidemiology 47:1021-26, 1994.


Antioxidant Functions

Antioxidants are well documented and known to play vital roles in health maintenance and disease prevention. Glutathione is your cell's own major antioxidant. Maintaining elevated glutathione levels aids the body's natural antioxidant function.

Biochemical Pharmacology 47: 2114-2123, 1994.

Neurological Disease

Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's Disease), Alzheimer's and Parkinson's. The Lancet 344: 796-798, 1994.

Cancer

Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/anti-tumor defenses.

Cancer Letters 57: 91-94, 1991.

Athletic Performance

Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge. Journal of Applied Physiology 87: 1381-1385, 1999.

Toxins, Pollution and Radiation

Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer.
Annual Reviews of Biochemistry 52: 711-760, 1983
AIDS

Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS.

Proceedings of the National Academy of Science, USA 94: 1967-72, 1997.

Heart Disease, Stroke and Cholesterol

Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes.

Nutrition Reviews 54: 1-30, 1996.

Diabetes

Diabetics are more prone to 'out-fections' and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes.

Clinical Science 91:575-582, 1996

Lung Disease

Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses.

American Journal of Medical Science 307:119-127, 1994

Digestive Disorders

Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn's disease.

Gut 42: 485-492, 1998

Hepatitis

The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raised glutathione levels help restore liver function.

American Journal of Gastroenterology 91: 2569-2573, 1996

Kidney Disease

Those with kidney failure or on dialysis suffer from high levels of oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia.

Nephron 61: 404-408, 1992

Pregnancy, Lactation and Childbirth

Glutathione's role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels.