Diseases Associated With Decreased Glutathione

Health issues of our time:

GENERAL
* Obesity
* immune Signaling
* Endothelial dysfunction
* Alcoholism
* Inflammation
* Heavy Metal poisoning


CARDIOVASCULAR
* Angina and spastic angina
* Unstable angina
* Heart Attacks
* Positive stress test
* Referfusion after 
Cardiac bypass surgery

PULMONARY
* Emphysema (COPD)
* Pulmonary Fibrosis (IPF)
* Asthma
* Muscle wasting in COPD
* Chronic bronchitis
* Tobacco abuse

NEURO/PSYCH
* Migraine headaches
* Alzheimer’s
* Parkinson’s
* Multi infarct dementia
* Autism
* ADHD (Attention Deficit
Hyperactivity Disorder
* Bipolar disease
* Schizophrenia
* Lou Gehrig’s disease
* Huntington’s chorea
* Multiple Sclerosis (MS)
* Depression

INFECTIOUS DISEASES/IMMUNOLOGY
* Hepatitis A,B and C
* Herpes Simplex
* Herpes Zoster/shingles
* Influenza and bird flu
* HIV
* MRSA
* Common viral infections (upper
Respiratory gastroenteritis

RHEUMATOLOGY
* Systemic Lupus Erythematosus (SLE)
* Rheumatoid Sclerosis (RA)
* Behcet’s Syndrome
* Fibromyalgea

DERMATOLOGY
* Wrinkles, sagging
* Acne
* Psoriasis
* Atopic dermatitis
* Eczema

ONCOLOGY
Every cancer studied including:
* Brain
* Head and neck
* Thyroid
* Lung
* Esophagus
* Stomach
* Intestine
* Liver
* Pancreas
* Kidney
* Uterine
* Ovarian
* Prostate
* Leukemia (acute and chronic)
* Lymphoma
* Multiple myeloma

OB/GYN
* Infertility
* Spontaneous abortions
* Pre-menstrual syndrome

OPTHALMOLOGY
* Cataracts
* Macular degeneration

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Glutathione Can Cut Risk Of Breast Cancer

Researchers wanted to find out if there was any correlation between breast cancer risk and blood serum levels of cysteine – an amino acid and precursor of glutathione, the intracellular antioxidant that I’ve told you about many times.

Taking the lead from previous studies that have shown glutathione to be capable of detoxifying carcinogens, the Brigham researchers examined blood sample data from more than 700 breast-cancer patients. All patient records were matched with records of subjects who were healthy and of similar age.

The most dramatic results were recorded among pre-menopausal women. In this group, women who had the highest levels of cysteine were more than 75 percent less likely to develop breast cancer than those with the lowest cysteine levels. And the risk was reduced even more among women who had normal body weight.

Post-menopausal women with the highest cysteine levels also fared well, reducing their breast cancer risk by almost half compared to women with the lowest levels.

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This article below was reposted from Daily Health UK

Three recent e-Alerts about mammography prompted a batch of member comments that could be called a ‘heated debate’ – some arguing that mammograms are necessary, while others offered experiences that would make anyone think twice about signing on for the procedure when less problematic screening tools are available.

Today, however, I’ll calm the waters with a subject we can all agree on: An effective way to prevent breast cancer would be a welcome addition to any screening process a woman might choose. Fortunately, new evidence shows that an important amino acid may provide significant breast cancer prevention.

Something in the blood
At last month’s American Association for Cancer Research meeting, researchers from Brigham and Women’s Hospital and Harvard School of Public Health released the results of a new study using data from the Nurses’ Health Study.

Researchers wanted to find out if there was any correlation between breast cancer risk and blood serum levels of cysteine – an amino acid and precursor of glutathione, the intracellular antioxidant that I’ve told you about many times.

Taking the lead from previous studies that have shown glutathione to be capable of detoxifying carcinogens, the Brigham researchers examined blood sample data from more than 700 breast-cancer patients. All patient records were matched with records of subjects who were healthy and of similar age.

The most dramatic results were recorded among pre-menopausal women. In this group, women who had the highest levels of cysteine were more than 75 percent less likely to develop breast cancer than those with the lowest cysteine levels. And the risk was reduced even more among women who had normal body weight.

Post-menopausal women with the highest cysteine levels also fared well, reducing their breast cancer risk by almost half compared to women with the lowest levels.

In the conclusions to the Brigham study, lead author Shumin Zhang named a specific supplement, known to boost cysteine levels. Zhang wrote: ‘N-acetylcysteine, a synthetic precursor of cysteine, might have the potential to be chemopreventive against breast cancer.’

The glutathione factor
N-acetylcysteine (NAC) enhances the production of glutathione, one of the body’s most powerful antioxidant enzymes. Glutathione is found in every cell of the body (most notably in immune system cells), which is one of the reasons why its antioxidant action is so effective in protecting against disease and repairing damage throughout the body. In addition, glutathione is believed to protect other antioxidants (among them, vitamins C and E), prolonging and enhancing their effectiveness. It also acts directly against certain carcinogenic substances by binding to these toxins and eliminating them through urine or bile.

But all of this effectiveness comes at a price. Because when the immune system is taxed (by everything from pollution, to poor diet, infection, radiation, emotional stress, and all types of trauma), stores of glutathione become depleted. Drugs can also take their toll. In fact, acetaminophen has been shown to deplete glutathione stores in the liver. And as if all of that weren’t enough, our glutathione levels tend to steadily drop as we grow older.

Miss Muffet was right

Fortunately there are good food sources that deliver glutathione precursors, including meats and fresh fruits and vegetables. But even with a diet high in the proteins that supply glutathione amino acids, one of those amino acids – cysteine – is more difficult than the others to come by. And that’s why N-acetylcysteine (note the ‘cysteine’) is so important as an effective glutathione booster.

There’s also a natural food component with high concentrations of glutathione precursors (including cysteine) called milk-serum-protein concentrate – more simply known as whey. For those who avoid dairy in their diets, whey will not be an answer. For others, however, the proteins found in milk whey (serum albumin, alpha lactalbumin, and lactoferrin) all contribute to the effectiveness of the glutathione precursors.

More to come
The Brigham breast cancer study calls for the next logical step in research: a double-blind placebo trial in which a large group of women, both menopausal and pre-menopausal, are tested with supplements known to boost cysteine levels. In an interview with BioMedNet News, Mr. Zhang mentioned only two cysteine precursors, NAC and Immunocal.

Hopefully researchers will take the hint and focus on these two agents that could impact the prevention of breast cancer for years to come. I’ll watch for further research, and will report to you as soon as the studies are published.

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Mesothelioma Lung Cancer or Pneumonia

The two most common symptoms of pleural mesothelioma are breathing difficulties and chest pain. These symptoms usually develop as a result of fluid accumulation in the area around the lungs, also known as pleural effusion, or tumors that suppress the lung wall and thorax.

There are differences in symptoms depending on whether the pneumonia is bacterial or viral, but its main symptoms are very much to mimic mesothelioma. When people consult a doctor with these symptoms, they are almost always suspected of suffering from pneumonia, and not mesothelioma. Treatment will be given as such and since this treatment will likely overcome some pleural effusions, people will feel better and consider their doctor correct with his diagnosis.

Interestingly, 25% of patients with mesothelioma have symptoms of pleural effusion before visiting a doctor.

Another reason why mesothelioma and pneumonia are often confused is because the patient experiences pleural thickening. This means the pleura becomes a scar and the lungs lose their elasticity. When this happens, normal breathing worsens. Some diseases can cause this, more commonly than mesothelioma, and include pneumonia, empyema, pleuritis and tuberculosis.

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What Is Mesothelioma?

This is a repost from:
https://mpl.mesotheliomahelpnow.com

What Is Mesothelioma?
Mesothelioma is a type of cancer that affects the protective linings (mesothelium) that cover different organs. Mesothelioma is becoming a well-known health crisis due to its association with asbestos exposure. By nature, mesothelioma takes 10-50 years to produce symptoms after the initial asbestos exposure, making a diagnosis shocking and devastating to patients and their families.

Depending on how the cancer forms, it can affect the linings of the lungs and chest (pleura), the abdominal organs (peritoneum) or the heart (pericardium).

Pleural Mesothelioma
Mesothelioma located within the protective lining that covers the lungs and chest wall (pleura). It accounts for roughly 80-85% of all mesothelioma cases that are diagnosed. Pleural mesothelioma is aggressive and has a poor prognosis. Ongoing research into pleural mesothelioma treatments is giving patients a better chance at long-term survival by combining chemotherapy, radiation, and surgery along with new and promising therapies.

Pleural Mesothelioma Symptoms
Chest pain
Dry, persistent cough
Difficulty breathing
Fluid buildup in the lungs (pleural effusions)
Unexplained weight loss
Fever
Fatigue
Peritoneal Mesothelioma
When mesothelioma forms in the lining of the abdominal organs (peritoneum) it’s called peritoneal mesothelioma. The second most common form of the disease, peritoneal mesothelioma accounts for 15-20% of mesothelioma cases.

With the best prognosis of all three primary disease locations, peritoneal mesothelioma patients benefit from effective multimodal treatments involving surgery and direct chemotherapy.



Pericardial Mesothelioma
Pericardial mesothelioma occurs when mesothelioma tumors form in the protective sac that covers the heart organ (pericardium). The rarest form of the disease, pericardial mesothelioma accounts of less than 1% of all known mesothelioma cases.

Researchers are still unsure of how pericardial mesothelioma forms—an understanding made more difficult by the fact that the majority of cases aren’t diagnosed until autopsy.

Pericardial Mesothelioma Symptoms
Chest pain
Difficulty breathing
Heart irregularities (palpitations and murmurs)
Fluid buildup in the heart sac (pericardial effusions)
Heart inflammation (pericarditis)
Fever
Fatigue
Who Gets Mesothelioma?
Mesothelioma can affect anyone, at any age, and of any background. Sadly, it can affect even the healthiest and most active people, including young adults. However, mesothelioma predominantly affects older people over the age of 65, and the vast majority are males.

Roughly 30% of mesothelioma victims are veterans, with the majority of these victims being past Navy members.

The reason mesothelioma affects this older male demographic, is because it’s caused by asbestos. As an industrial and construction material, it was mostly men who were exposed to asbestos during their careers in the military or emergency services, or as mechanics, construction workers or other industrial trades.


Because asbestos exposure is the direct cause of mesothelioma, many victims wonder about what asbestos is and how it can cause such a deadly disease. They may feel confused and seek out answers as to why asbestos was even used in the first place. Frustration is common, and empowering yourself with information regarding asbestos use and mesothelioma can help you to cope with your diagnosis.

What Causes Mesothelioma?
Asbestos is the only known cause of developing mesothelioma. Classified as a group of minerals, asbestos is extracted from the ground in places around the world, including the United States and Canada. When asbestos mining began in the mid 20th Century, it was seen as a tremendous industrial discovery. Asbestos was used extensively in the military and construction projects across the globe.

It soon became apparent to asbestos producers that there were severe health risks associated with handling asbestos. Instead of informing asbestos purchasers of these dangers, the manufacturers ignored the signs in what is now considered a well-known cover-up attempt.

How Asbestos Leads to Mesothelioma
Asbestos is dangerous because if distributed through handling, it releases its fibers into the air. Anyone working around the materials is at risk of inhaling or ingesting asbestos fibers. However, because the fibers are so tiny, victims never know they’re swallowing or breathing them in.

After inhaling or ingesting asbestos fibers, mesothelioma victims feel no effect. Instead, the fibers remain unnoticed inside the body and make their way into the deep tissue linings of the lungs, abdomen or heart. Where the fibers end up depends on how you contacted the asbestos. You could have breathed them in, or you could have swallowed them if they ended up in your drinking water or food.

The Mesothelioma Formation Process:

Over time, the asbestos fibers further lodge themselves deeper and deeper into the mesothelium of the organs.
Following decades of dormancy, the fibers can start to irritate the tissues, causing inflammatory reactions within healthy cells.
After enough irritation, the once healthy cells may become triggered and turn into abnormal, cancer cells.
When enough cancer cells form within the organ linings, they can soon outnumber healthy cells. As cancer cells clump together and form tumors (masses of cancerous tissue), it becomes the condition known as mesothelioma.
What’s My Life Expectancy?
The general life expectancy for mesothelioma patients is very short compared to some other, more well-researched cancers, like lung and breast cancers.

After diagnosis, the average mesothelioma life expectancy is only 12 to 21 months.

It’s important to note that mesothelioma statistics are based on historical data and don’t always reflect the truth about what a mesothelioma patient can expect. The truth is that mesothelioma affects each patient differently. Your life expectancy has a lot to do with your individual circumstances.

Some factors that will determine your life expectancy include:

Where the mesothelioma is located
The mesothelioma cell-type
The stage at which you were diagnosed
Your body’s response to treatments
Your age and personal health level, including lifestyle and medical history
For example, if doctors detect mesothelioma in the early stages, the average life expectancy is greater than 21 months. But late-stage mesothelioma patients have an average life expectancy of only 12 months.

Mesothelioma Survival Rates
Doctors determine your life expectancy based on your unique case as well as past cases that they can draw expectations from. One of the ways doctors determine life expectancy is by looking at survival rates of mesothelioma.

By taking a specific timeframe and determining the percentage of people who survived that long, experts come up with the “survival rate”. Here are examples of mesothelioma survival rates that may indicate how long patients will live after diagnosis:

Some patients don’t wish to see survival statistics.

Here are some of the typical mesothelioma survival rates:

55% of patients survive 6 months
33% of patients survival 1 year
9% of patients survive 5 years
Though these statistics may seem bleak, it’s important for mesothelioma patients to know that these numbers encompass decades of cases. In earlier years, mesothelioma was virtually untreatable as little was known about it.

Today, long-term survivorship has improved dramatically thanks to new therapies and better research. With aggressive treatments, many patients have survived longer than 10 years, and there are many long-term survivors still alive today.

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